Stem Cells

doi:10.1093/ maven/awh553 Brain (2005), 128, 20342041 Cerebral small-vessel disease and rase out in information touch on speed, executive usance and memory Niels D. Prins,1,2 Ewoud J. van Dijk,1,2 Tom retreat Heijer,1,2 Sarah E. Vermeer,1,2 Jellemer Jolles,3 Peter J. Koudstaal,1 Albert Hofman2 and Monique M. B. Breteler2 1 3 Department of Neurology and 2Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam and Department of Neuropsychology, mental medicine and Psychobiology, University of Maastricht, Maastricht, The Netherlands Cerebral small-vessel disease is common in cured hoi polloi and may contribute to the development of dementia. The objective of the present ruminate was to evaluate the relationship between measures of intellectual small-vessel disease on MRI and the prise of change state in speci?c cognitive domains in participants from the prospective, population-based Rotterdam Scan Study. Participants were 6090 d ays of season and free from dementia at baseline in 19951996. White subject field lesions (WML), cerebral infarcts and generalized brain atrophy were assessed on the baseline MRI. We performed neuropsychological testing at baseline and tellly in 19992000 and in 20012003.

We used random-effects models for repeated measures to examine the association between vicenary MRI measures and rate of decrease in measures of global cognitive function, information processing speed, executive function and memory. There were a total of 2266 sagacitys for the 832 participants in the study, with an average time from the i nitial to in the end assessment of 5.2 year! s. Increasing severity of periventricular WML and generalized brain atrophy and the former man of brain infarcts on MRI were associated with a steep-sided decline in cognitive function. These structural brain changes were speci?cally associated with decline in information processing speed and executive function. The associations between MRI measures of cerebral small-vessel...If you want to get a amply essay, order it on our website: BestEssayCheap.com

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